Search results for " Contrast agents"
showing 7 items of 7 documents
SIRM-SIAAIC consensus, an Italian document on management of patients at risk of hypersensitivity reactions to contrast media
2020
Abstract Hypersensitivity reactions (HRs) to contrast media (CM) can be distinguished in immune-mediated (including allergic reactions) and non-immune-mediated reactions, even if clinical manifestations could be similar. Such manifestations range from mild skin eruptions to severe anaphylaxis, making it important for radiologists to know how to identify and manage them. A panel of experts from the Società Italiana di Radiologia Medica e Interventistica (SIRM) and the Società Italiana di Allergologia, Asma e Immunologia Clinica (SIAAIC) provided a consensus document on the management of patients who must undergo radiological investigations with CM. Consensus topics included: the risk stratif…
Minor changes in the macrocyclic ligands but major consequences on the efficiency of gold nanoparticles designed for radiosensitization
2016
International audience; Many studies have been devoted to adapting the design of gold nanoparticles to efficiently exploit their promising capability to enhance the effects of radiotherapy. In particular, the addition of magnetic resonance imaging modality constitutes an attractive strategy for enhancing the selectivity of radiotherapy since it allows the determination of the most suited delay between the injection of nanoparticles and irradiation. This requires the functionalization of the gold core by an organic shell composed of thiolated gadolinium chelates. The risk of nephrogenic systemic fibrosis induced by the release of gadolinium ions should encourage the use of macrocyclic chelat…
Synthesis, Stability and Relaxivity of TEEPO-Met: An Organic Radical as a Potential Tumour Targeting Contrast Agent for Magnetic Resonance Imaging
2018
Cancer is a widespread and life-threatening disease and its early-stage diagnosis is vital. One of the most effective, non-invasive tools in medical diagnostics is magnetic resonance imaging (MRI) with the aid of contrast agents. Contrast agents that are currently in clinical use contain metals, causing some restrictions in their use. Also, these contrast agents are mainly non-specific without any tissue targeting capabilities. Subsequently, the interest has notably increased in the research of organic, metal-free contrast agents. This study presents a new, stable organic radical, TEEPO-Met, where a radical moiety 2,2,6,6-tetraethylpiperidinoxide (TEEPO) is attached to an amino acid, methio…
Gadolinium-chelating nanogels as MR contrast agesnts specifically targeting tumor cells
2014
Development of multifunctional nanogels coordinating paramagnetic ions and displacing targeting ligands for preferential accumulation into tumors. Low molecular-weight Gd-chelates are widely used in clinical MRI for various purposes. However, these contrast agents (CAs) have several shortcomings: they rapidly extravasate from blood vessels to the interstitial space, have a short circulation times and show poor contrast at high magnetic fields. Incorporating gadolinium into flexible nanogels has the potential of increasing intravascular half-life, accumulation and retention in specific body compartments of the CA as well as increasing the MR signal, since many metal ions can be coordinated t…
Lanthanide complexes as imaging agents anchored on nano-sized particles of boehmite
2011
International audience; The synthesis of boehmite nanoparticles modified with lanthanides (Eu, Tb and Gd) is described. Their synthesis, characterization and in vitro assays with HeLa cells were performed. The nuclear magnetic relaxation dispersion (NMRD) profiles of the two chelating moieties were studied. Imaging data from laser scanning confocal fluorescence microscopy and flow cytometry revealed that the nanoscaffolds were taken up by the cells, distributed throughout the cytoplasm and showed no toxicity. This platform could represent an alternative to silica-based inert matrices as imaging vehicles.
Gadolinium-chelating nanogels as MR contrast agents specifically targeting tumor cells
2014
Aims and objectives Methods and materials Results Conclusion Personal information References
SAFETY OF REPEATED MDCT WITH CONTRAST COMPOUND IN CASE OF PREVIOUS MILD OR MODERATE ADVERSE REACTION: A SINGLE CENTRE RETROSPECTIVE STUDY.
2015
Aims and objectives Methods and materials Results Conclusion Personal information References